General Information

  • ID:  hor001363
  • Uniprot ID:  A0A8J5MJP5
  • Protein name:  FMRFamide-related peptide
  • Gene name:  NA
  • Organism:  Homarus americanus (American lobster)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GAHKNYLRF
  • Length:  9
  • Propeptide:  MIVAAWVLLTTLTWCCQAHAAPVPPVVAALDPPTDALLPAQSQEDDLFALPEKRLLKYFLPASQAWGGDAYPIGQEGTKRGYSDRNYLRFGRSDTNDYEGEEMPESPEKRNRNFLRFGRDQNRNFLRFGRSGSPMEFATDLQEDVELPVEEKRGAHKNYLRFGRGNRNFLRFGRGDRNFLRFGRSVDRQLSSLSCEDCDEEQKAREFTSTPSPTTIQPLARTKRDVSAVLSDDSIESSVLRQINAHRIKRAAAQNFYIPMAWASELQPEEDGIDVTSFEEPQVAKRFSHDRNFLRFGKRDGSDDYPSSSSSAESPAPVVVVRPVEYPRYVRAPSKNFLRFG
  • Signal peptide:  MIVAAWVLLTTLTWCCQAHA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001363_AF2.pdbhor001363_ESM.pdb

Physical Information

Mass: 124814 Formula: C51H76N16O12
Absent amino acids: CDEIMPQSTVW Common amino acids: AFGHKLNRY
pI: 10.45 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -93.33 Boman Index: -2126
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 54.44
Instability Index: 3773.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  22860213
  • Title:  Mass Spectral Charting of Neuropeptidomic Expression in the Stomatogastric Ganglion at Multiple Developmental Stages of the Lobster Homarus Americanus